Synthesis and Structure-Activity relationships of fused imidazopyridines: a new series of benzodiazepine receptor ligands

…, N Chomei, M Adachi, T Fujishita, M Eigyo…

文献索引：Takada, Susumu; Sasatani, Takashi; Chomei, Nobuo; Adachi, Makoto; Fujishita, Toshio; Eigyo, Masami; Murata, Shunji; Kawasaki, Kazuo; Matsushita, Akira Journal of Medicinal Chemistry, 1996 , vol. 39, # 14 p. 2844 - 2851

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被引用次数: 20

摘要

2-Arylimidazo [4, 5-c] quinolines and analogous fused imidazopyridines were synthesized and evaluated as benzodiazepine receptor ligands. Affinity to the receptors was greatly affected by the bulkiness of the aryl group at the 2-position, compared to the pyrazoloquinolines such as CGS-9896. Derivatives with an isoxazole moiety at the 2- position showed high binding affinity and in vivo activity. In the imidazo [4, 5-c] quinoline ...