Journal of the American Chemical Society

The Synthesis of Some 3-Nitro-and 3-Amino-4-dialkylaminoalkylaminoquinoline Derivatives

AR Surrey, RA Cutler

文献索引：Surrey; Cutler Journal of the American Chemical Society, 1951 , vol. 73, p. 2413,2414

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被引用次数: 12

摘要

The nitration of 4-hydroxy-, 5-(and 7)-chloro-4-hydroxyquinolines with hot concentrated nitric acid to give the corresponding 3-nitro compounds is reported. The 4-hydroxy group was replaced with chlorine to yield the 4-chloro-3-nitroquinolines which in turn reacted with ammonia, aniline and 3-diethylamino-2-hydroxypropylamine to give the 4-amino-, 4-anilino- and 4-(3-diethylamino-2-hydroxypropylamino)-3-nitroquinoline derivatives. The ...