1H-imidazo [4, 5-c] quinolin-4-amines: novel non-xanthine adenosine antagonists

…, P Nissen, I Van Wijngaarden…

文献索引：Galen, Philip J. M. van; Nissen, Peter; Wijngaarden, Ineke van; IJzerman, Adriaan P.; Soudijn, Willem Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1202 - 1206

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被引用次数: 53

摘要

A, receptor. Furthermore, it was expected that certain hydrophobic substitutions at the 2-and 4-positions would enhance affinity. Here, we report on the synthesis and the adenosine AI and A2 receptor affinity of substituted 1H-imidazo [4, 5-c] quinolin-4-amines. Some of these compounds have nanomolar affinity for the AI receptor. The structure-activity relationships (SAR) of these compounds are discussed in relation to SAR for other adenosine receptor ...