Tetrahedron

Solution conformational analysis, crystal structure determination, and anticancer activity of ring-constrained 1, 3, 2-dioxa-and oxazaphosphorinane cyclophosphamide …

JC Yang, DO Shah, NUM Rao, WA Freeman…

文献索引：Yang; Shah; Rao; Freeman; Sosnovsky; Gorenstein Tetrahedron, 1988 , vol. 44, # 20 p. 6305 - 6314

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被引用次数: 26

摘要

Conformational analysis of 2-[bis-(2-chloroethyl) amino]-2-trans-tetramethylene-1, 3, 2-dioxa- and oxazaphosphorinanes 5–8, cyclophosphamide-type anticancer drugs, show that diastereometric six-membered ring 1, 3, 2-dioxaphosphor-inanes can adopt either a chair conformation with bis-(2-chloroethyl) amino mustard group equatorial (5) or twist-boat conformation with the bis-(2-chloroethyl) amino group pseudoequatorial (6). An X-ray ...