Direct catalytic asymmetric aldol reaction: synthesis of either syn-or anti-α, β-dihydroxy ketones

…, T Ohshima, T Suzuki, M Shibasaki

文献索引：Yamasaki; Kanai; Shibasaki Journal of the American Chemical Society, 2001 , vol. 123, # 6 p. 1256 - 1257

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被引用次数: 188

摘要

The development of a range of catalytic asymmetric aldol reactions has proven to be a valuable contribution to asymmetric synthesis. 1 In all of these catalytic asymmetric aldol reactions, however, preconversion of the ketone moiety to a more reactive species such as an enol silyl ether and ketene silyl acetal is an unavoidable necessity. Thus, the development of a direct catalytic asymmetric aldol reaction is highly desirable in terms of ...