Tetrahedron letters

Easy direct stereo-and regioselective formation of β-hydroxy nitriles by reaction of 1, 2-epoxides with potassium cyanide in the presence of metal salts

M Chini, P Crotti, L Favero, F Macchia

文献索引：Chini, Marco; Crotti, Paolo; Favero, Lucilla; Macchia, Franco Tetrahedron Letters, 1991 , vol. 32, # 36 p. 4775 - 4778

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被引用次数: 80

摘要

Abstract A simple efficient, anti stereoselective, and highly regioselective method for the synthesis of β-hydroxy nitriles by the direct opening of 1, 2-epoxides with KCN in acetonitrile, in the presence of metal salts, is described. This new method appears to be competitive with the other methods previously reported.