Il Farmaco

Synthesis and anti-HIV activity of C4-modified pyrimidine nucleosides

MP Wallis, N Mahmood, W Fraser

文献索引：Wallis, Mark P.; Mahmood, Naheed; Fraser, William Farmaco, 1999 , vol. 54, # 1-2 p. 83 - 89

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被引用次数: 12

摘要

One-pot syntheses provided a series of triazole-and pentafluorophenyloxy-substituted pyrimidine nucleosides. Most of the compounds in the series displayed anti-HIV activities but none as potent as AZT 2. 1-(β-d-Erythro-pentofuranosyl)-4-pentafluorophenyloxy-2 (1H)- pyrimidinone 14 was the most potent and the most selective compound in the series with EC50= 1.6 μM.