Tetrahedron letters

Reaction between nucleoside base residues and the phosphorylating agent derived from 1-hydroxybenzotriazole and 2-chloroprenyl phosphorodichloridate

CB Reese, KH Richards

文献索引：Reese, Colin B.; Richards, Keith H. Tetrahedron Letters, 1985 , vol. 26, # 18 p. 2245 - 2248

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被引用次数: 28

摘要

For a number of years, we have successfully used 2-chlorophenyl phosphorodi-(1, 2, 4- triazolide)(a) as the phosphorylating agent in the first phosphorylation step'of the phosphotriester approach2 to oligonucleotide synthesis. Despite the susceptibility of the 2-E- acylguanine3, thymine and uracil