Nucleomimetic strategy for the inhibition of HIV-1 nucleocapsid protein NCp7 activities

…, H Meudal, BP Roques, MC Fournié-Zaluski

文献索引：Druillennec, Sabine; Meudal, Herve; Roques, Bernard P.; Fournie-Zaluski, Marie-Claude Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 4 p. 627 - 632

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被引用次数: 9

摘要

We report the synthesis and biological properties of three modified dinucleotides T∗ G, G∗ T and T∗ T in which the natural phosphodiester linkage has been replaced by a methylene carboxamide unit. They have been designed to act as nucleomimetics of a sequence recognized by the HIV-1 nucleocapsid protein NCp7 and to inhibit this interaction.