Bioorganic & medicinal chemistry

Deoxynucleic guanidine: synthesis and incorporation of purine nucleosides into positively charged DNG oligonucleotides

H Challa, TC Bruice

文献索引：Challa, Hemavathi; Bruice, Thomas C. Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 6 p. 1475 - 1481

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被引用次数: 15

摘要

The synthesis of purine nucleosides capable of making the guanidinium linkage is described for the first time starting from the corresponding 2′-deoxynucleosides. The positively charged mixed base DNG oligomer containing guanine was synthesized on solid- phase using CPG as support from 3′ to 5′ direction using the precursor building block nucleosides.