Microwave Assisted High Yielding Preparation of N-Protected 2′-Deoxyribonucleosides Useful for Oligonucleotide Synthesis

NS Rao, P Kumar, VK Chauhan, BS Garg…

文献索引：Rao; Kumar; Chauhan; Garg; Gupta Nucleosides, Nucleotides and Nucleic Acids, 2002 , vol. 21, # 4-5 p. 393 - 400

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被引用次数: 13

摘要

ABSTRACT A rapid and high yielding method for the synthesis of precursors of synthons for DNA synthesis, N-protected 2′-deoxyribonucleosides is described, which occur under mild conditions using microwave irradiation. The desired material, N-protected nucleosides, was obtained in 93–96% yield in few minutes. The final products were then characterized by 1H- NMR and MALDI-TOF and compared with the standard samples. The method is amenable ...