Tetrahedron letters

A convenient synthesis of 5′-amino-5′-deoxythymidine and preparation of peptide-DNA hybrids

CN Tetzlaff, I Schwope, CF Bleczinski, JA Steinberg…

文献索引：Tetzlaff, Charles N.; Schwope, Ina; Bleczinski, Colleen F.; Steinberg, Joshua A.; Richert, Clemens Tetrahedron Letters, 1998 , vol. 39, # 24 p. 4215 - 4218

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被引用次数: 61

摘要

5′-Amino-5′-deoxythymidine was prepared from thymidine in two steps and converted to its known 5′-methoxytrityl-protected 3′-phosphoramidite building block for DNA assembly on solid supports. Using this building block, peptide-DNA hybrids were synthesized in stepwise manner or via fragment condensation, both as single compounds and as small combinatorial libraries.