Novel bicyclic lactam inhibitors of thrombin: potency and selectivity optimization through P1 residues

S Levesque, Y St-Denis, B Bachand, P Preville…

文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 24 p. 3161 - 3164

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被引用次数: 14

摘要

... Bioorganic & Medicinal Chemistry Letters. ... We planned to compensate for this reduction in potency by incorporating additional chemical features in the inhibitors, primarily through introduction of various P1 residues. ...