Discovery of diaminobutane derivatives as Ca 2+-permeable AMPA receptor antagonists

Y Yoneda, T Mimura, K Kawagoe, T Yasukouchi…

文献索引：Yoneda, Yoshiyuki; Mimura, Tetuya; Kawagoe, Keiichi; Yasukouchi, Takanori; Tatematu, Toshiaki; Ito, Masayuki; Saito, Masaki; Sugimura, Masunobu; Kito, Fusako; Kawajiri, Shinichi Bioorganic and medicinal chemistry, 2002 , vol. 10, # 5 p. 1347 - 1359

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被引用次数: 6

摘要

We designed and synthesized a series of the polyamine derivatives as potent Ca2+- permeable AMPA receptor antagonists. In the course of this study, we found that the polyamine derivatives exhibited strong hypotensive activity which was undesirable activity for neuroprotective agents. Therefore, we tried to find non-hypotensive antagonists by structural modification of such compounds. Through this derivatization, we obtained the ...