Novel bicyclic lactam inhibitors of thrombin: potency and selectivity optimization through P1 residues

S Levesque, Y St-Denis, B Bachand, P Preville…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 24 p. 3161 - 3164

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Citation Number: 14

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... We planned to compensate for this reduction in potency by incorporating additional chemical features in the inhibitors, primarily through introduction of various P1 residues. ...

Novel bicyclic lactam inhibitors of thrombin: potency and se...

[Levesque, Sophie; St-Denis, Yves; Bachand, Benoit; Preville, Patrice; Leblond, Lorraine; Winocour, Peter D; Edmunds, Jeremy J; Rubin; Siddiqui Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 24 p. 3161 - 3164]

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