An improved preparation of 3, 5-bis (trifluoromethyl) acetophenone and safety considerations in the preparation of 3, 5-bis (trifluoromethyl) phenyl Grignard reagent
…, FR Tsay, U Dolling, T Vickery, D Bachert
文献索引：Leazer Jr., Johnnie L.; Cvetovich, Raymond; Tsay, Fuh-Rong; Dolling, Ulf; Vickery, Thomas; Bachert, Donald Journal of Organic Chemistry, 2003 , vol. 68, # 9 p. 3695 - 3698
An improved and efficient bromination of 3, 5-bis (trifluoromethyl) benzene was developed. A safe and reliable preparation of the potentially explosive 3, 5-bis (trifluoromethyl) phenyl Grignard and 3-trifluoromethylphenyl Grignard reagents, from the precursor bromides, is described. Reaction System Screening Tool (RSST) and Differential Thermal Analysis (DTA) studies suggest these trifluoromethylphenyl Grignard reagents can detonate on loss of ...
