An improved preparation of 3, 5-bis (trifluoromethyl) acetophenone and safety considerations in the preparation of 3, 5-bis (trifluoromethyl) phenyl Grignard reagent

…, FR Tsay, U Dolling, T Vickery, D Bachert

Index: Leazer Jr., Johnnie L.; Cvetovich, Raymond; Tsay, Fuh-Rong; Dolling, Ulf; Vickery, Thomas; Bachert, Donald Journal of Organic Chemistry, 2003 , vol. 68, # 9 p. 3695 - 3698

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Citation Number: 65

Abstract

An improved and efficient bromination of 3, 5-bis (trifluoromethyl) benzene was developed. A safe and reliable preparation of the potentially explosive 3, 5-bis (trifluoromethyl) phenyl Grignard and 3-trifluoromethylphenyl Grignard reagents, from the precursor bromides, is described. Reaction System Screening Tool (RSST) and Differential Thermal Analysis (DTA) studies suggest these trifluoromethylphenyl Grignard reagents can detonate on loss of ...