Synthesis and biological characteristics of the Technetium??99m triamide derivatives of mercaptoacetyltriglycine (MAG3)

…, P Adriaens, AM Verbruggen

文献索引：Okarvi; Verbeke; Adriaens; Verbruggen Journal of Labelled Compounds and Radiopharmaceuticals, 2002 , vol. 45, # 2 p. 115 - 137

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被引用次数: 7

摘要

Abstract A number of MAG 3-derivatives, containing the three-amide functions modified by inverting the sequence–CO–NH–to–NH–CO–in the first-and/or second-amide functions, have been labelled with 99m Tc in order to study the renal characteristics of the resulting MAG 3-derivatives versus the reference 99m Tc-MAG 3. The 99m Tc-MAG 3-derivatives displayed HPLC-profiles similar to that of 99m Tc-MAG 3. Furthermore, in mice they ...