Synthesis and cytotoxic activities of β-carboline amino acid ester conjugates

M Zhao, L Bi, W Wang, C Wang, M Baudy-Floc'h…

文献索引：Zhao, Ming; Bi, Lanrong; Wang, Wei; Wang, Chao; Baudy-Floc'h, Michele; Ju, Jingfang; Peng, Shiqi Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 20 p. 6998 - 7010

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被引用次数: 90

摘要

β-Carboline represents a class of compounds with potent anti-tumor activity by intercalating with DNA. To further enhance the cytotoxic potency and bioavailability of β-carboline, a series of novel β-carboline amino acid ester conjugates were designed and synthesized, and the cytotoxic activities of these compounds were tested using a panel of human tumor cell lines. In addition, the membrane permeability of these compounds was evaluated in ...