A class of novel N-(1-methyl-β-carboline-3-carbonyl)-N′-(aminoacid-acyl)-hydrazines: Aromatization leaded design, synthesis, in vitro anti-platelet aggregation/in …

…, M Zhao, Y Wang, J Wu, J Liu, M Zheng, S Peng

文献索引：Li, Chunyu; Zhang, Xiaoyi; Zhao, Ming; Wang, Yuji; Wu, Jianhui; Liu, Jiawang; Zheng, Meiqing; Peng, Shiqi European Journal of Medicinal Chemistry, 2011 , vol. 46, # 11 p. 5598 - 5608

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被引用次数: 15

摘要

High anti-thrombotic activity of aminoacid modified tetrahydro-β-carbolines was generally correlated with a small proximity of the side chain of the aminoacid residue to the carboline- cycle. This paper explored that the aromatization of the tetrahydro-β-carboline-cycle of N-(1- methyl-β-tetrahydrocarboline-3-carbonyl)-N′-(aminoacid-acyl)-hydrazines leaded to N-(1- methyl-β-carboline-3-carbonyl)-N′-(aminoacid-acyl)-hydrazines and decreased the ...