Metabolism of curcuminoids in tissue slices and subcellular fractions from rat liver

…, E Pfeiffer, AM Sólyom, M Metzler

文献索引：Hoehle, Simone I.; Pfeiffer, Erika; Solyom, Aniko M.; Metzler, Manfred Journal of Agricultural and Food Chemistry, 2006 , vol. 54, # 3 p. 756 - 764

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被引用次数: 115

摘要

Curcumin and its natural congeners are of current interest because of their putative anti- inflammatory and anticarcinogenic activities, but knowledge about their metabolic fate is scant. In the present study conducted with precision-cut liver slices from male and female Sprague-Dawley rats, five reductive but no oxidative metabolites of curcumin and its demethoxy and bis-demethoxy analogues were observed and identified by HPLC and GC ...