Anti-allergic principles from Thai zedoary: structural requirements of curcuminoids for inhibition of degranulation and effect on the release of TNF-α and IL-4 in RBL- …

…, T Morikawa, A Nakamura, M Yoshikawa

文献索引：Matsuda, Hisashi; Tewtrakul, Supinya; Morikawa, Toshio; Nakamura, Akihiko; Yoshikawa, Masayuki Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 22 p. 5891 - 5898

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被引用次数: 111

摘要

The 80% aqueous acetone extract of the rhizomes of Curcuma zedoaria cultivated in Thailand (Thai zedoary) was found to inhibit release of β-hexosaminidase, as a marker of antigen-IgE-mediated degranulation, in RBL-2H3 cells and passive cutaneous anaphylaxis reaction in mice. From the active fraction, four curcuminoids (curcumin, dihydrocurcumin, tetrahydrodemethoxycurcumin, and tetrahydrobisdemethoxycurcumin) were isolated ...