Designing 129Xe NMR biosensors for matrix metalloproteinase detection

…, IE Dimitrov, NN Kuzma, IJ Dmochowski

文献索引：Wei, Qian; Seward, Garry K.; Hill, P. Aru; Patton, Brian; Dimitrov, Ivan E.; Kuzma, Nicholas N.; Dmochowski, Ivan J. Journal of the American Chemical Society, 2006 , vol. 128, # 40 p. 13274 - 13283

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被引用次数: 108

摘要

Xenon-129 biosensors offer an attractive alternative to conventional MRI contrast agents due to the chemical shift sensitivity and large nuclear magnetic signal of hyperpolarized 129Xe. Here, we report the first enzyme-responsive 129Xe NMR biosensor. This compound was synthesized in 13 steps by attaching the consensus peptide substrate for matrix metalloproteinase-7 (MMP-7), an enzyme that is upregulated in many cancers, to the ...