Analytical optical resolution of bromochlorofluoromethane by enantioselective inclusion into a tailor-made cryptophane and determination of its maximum rotation

J Canceill, L Lacombe, A Collet

文献索引：Canceill, Josette; Lacombe, Liliane; Collet, Andre Journal of the American Chemical Society, 1985 , vol. 107, # 24 p. 6993 - 6996

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被引用次数: 157

摘要

Abstract: Analytical optical resolution of bromochlorofluoromethane (1) has been achieved by IH NMR spectroscopy by inclusion of the haloform within the cavity of a chiral host molecule (5)(cryptophane-C) designed to fit substrates of this size. The diastereomeric 1: l complexes in which host (5) and guest (1) have like sign appear to be stabler than those formed from partners of unlike signs by about 1.1 kJ/mol. Under fast inclusion/exclusion ...