Designing 129Xe NMR biosensors for matrix metalloproteinase detection

…, IE Dimitrov, NN Kuzma, IJ Dmochowski

Index: Wei, Qian; Seward, Garry K.; Hill, P. Aru; Patton, Brian; Dimitrov, Ivan E.; Kuzma, Nicholas N.; Dmochowski, Ivan J. Journal of the American Chemical Society, 2006 , vol. 128, # 40 p. 13274 - 13283

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Citation Number: 108

Abstract

Xenon-129 biosensors offer an attractive alternative to conventional MRI contrast agents due to the chemical shift sensitivity and large nuclear magnetic signal of hyperpolarized 129Xe. Here, we report the first enzyme-responsive 129Xe NMR biosensor. This compound was synthesized in 13 steps by attaching the consensus peptide substrate for matrix metalloproteinase-7 (MMP-7), an enzyme that is upregulated in many cancers, to the ...