Journal of medicinal chemistry

… 2, 6-dimethyl-3, 5-bis (alkoxycarbonyl)-1, 4-dihydropyridines by human liver microsomes and immunochemical evidence for the involvement of a form of cytochrome P …

RH Boecker, FP Guengerich

文献索引：Boecker, Ronald H.; Guengerich, F. Peter Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1596 - 1603

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被引用次数: 362

摘要

4-Substituted 2, 6-dimethyl-3, 5-bis (alkoxycarbonyl)-1, 4-dihydropyridines are important because of their roles as calcium channel blockers. The mixed-function oxidation of 14 4- aryl-and four 4-alkyl-substituted derivatives by human liver microsomes was examined. The major product of enzymatic oxidation of all the 4-aryl compounds was the pyridine derivative containing the 4-aryl group. The 4-alkyl compounds, in contrast, formed a pyridine ...