Synthesis

Microwave-assisted oxidative aromatization of Hantzsch 1, 4-dihydropyridines using manganese dioxide

MC Bagley, MC Lubinu

文献索引：Bagley, Mark C.; Lubinu, M. Caterina Synthesis, 2006 , # 8 p. 1283 - 1288

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被引用次数: 58

摘要

Abstract 4-Aryl-and 4-alkyl-1, 4-dihydropyridines, prepared by microwave-assisted Hantzsch reaction, are readily and efficiently aromatized in only one minute using commercial manganese dioxide in the absence of an inorganic support at 100 C under microwave irradiation. This rapid procedure is more efficient than microwave-assisted aromatization using Pd/C, iodine or o-iodoxybenzoic acid (IBX) and gives the dehydrogenated or 4- ...