Tetrahedron letters

Microwave assisted combinatorial chemistry synthesis of substituted pyridines

…, DS Clark, JS Dordick, PC Michels, YL Khmelnitsky

文献索引：Cotterill, Ian C.; Usyatinsky, Alexander Ya.; Arnold, John M.; Clark, Douglas S.; Dordick, Jonathan S.; Michels, Peter C.; Khmelnitsky, Yuri L. Tetrahedron Letters, 1998 , vol. 39, # 10 p. 1117 - 1120

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被引用次数: 126

摘要

A new highly efficient MICROCOS technology (Microwave-assisted Combinatorial Synthesis) for generating combinatorial libraries is described. The technology is applied to the high throughput, automated, one-step, parallel synthesis of diverse substituted pyridines using the Hantzsch synthesis. The advantages of microwave-assisted chemistry for combinatorial synthesis include a broad range of available chemistries, simple reaction ...