Tetrahedron letters

Reinvestigation of the Wadsworth-Emmons reaction involving lithium difluoromethylenephosphonate

SR Piettre, L Cabanas

文献索引：Piettre, Serge R.; Cabanas, Leonora Tetrahedron Letters, 1996 , vol. 37, # 33 p. 5881 - 5884

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被引用次数: 37

摘要

Application of the published reaction conditions for the Wadsworth-Emmons transformation of ketones or aldehydes into 1, 1-difluoroolefins with lithium difluoromethy-lenephosphonate failed to give the expected product, affording instead phosphates of the general structure 9 in a nearly exclusive fashion. As variations of the conditions did not bring any change to the unexpected course taken by the reaction, a new procedure was worked out, that allows ...