Journal of fluorine chemistry

Synthesis of 1, 1-difluoroalkenes via α, α-difluoro-β-lactones

R Ocampo, WR Dolbier, R Paredes

文献索引：Ocampo, Rogelio; Dolbier, William R.; Paredes, Rodrigo Journal of Fluorine Chemistry, 1998 , vol. 88, # 1 p. 41 - 50

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被引用次数: 23

摘要

A new method for the general synthesis of 1, 1-difluoroalkenes from ketones is presented. The procedure involves initial condensation of a ketone with the difluoro Reformatsky reagent, hydrolysis to form the α, α-difluoro-β-hydroxy acids, followed by cyclization to make the novel α, α-difluoro-β-lactones. These are then thermally decarboxylated to form the 1, 1- difluoroalkenes.