Cross-coupling of aromatic bromides with allylic silanolate salts

SE Denmark, NS Werner

文献索引：Denmark, Scott E.; Werner, Nathan S. Journal of the American Chemical Society, 2008 , vol. 130, # 48 p. 16382 - 16393

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被引用次数: 62

摘要

The sodium salts of allyldimethylsilanol and 2-butenyldimethylsilanol undergo palladium- catalyzed cross-coupling with a wide variety of aryl bromides to afford allylated and crotylated arenes. The coupling of both silanolates required extensive optimization to deliver the expected products in high yields. The reaction of the allyldimethylsilanolate takes place at 85° C in 1, 2-dimethoxyethane with allylpalladium chloride dimer (2.5 mol%) to afford ...