Regioselective Metalations of Pyrimidines and Pyrazines by Using Frustrated Lewis Pairs of BF3⋅ OEt2 and Hindered Magnesium–and Zinc–Amide Bases

…, M Jaric, A Bredihhin, K Karaghiosoff…

文献索引：Groll, Klaus; Manolikakes, Sophia M.; Du Jourdin, Xavier Mollat; Jaric, Milica; Bredihhin, Aleksei; Karaghiosoff, Konstantin; Carell, Thomas; Knochel, Paul Angewandte Chemie - International Edition, 2013 , vol. 52, # 26 p. 6776 - 6780 Angew. Chem., 2013 , p. 6909 - 6913

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被引用次数: 31

摘要

The functionalization of diazines is of great importance, because these N-heterocycles are present in numerous natural products, pharmaceuticals, and agrochemicals.[1] They also find applications in materials science and polymer chemistry.[2] The directed metalation and further functionalization of these electron-deficient N-heterocycles can be realized with ate bases [3] and in some cases with lithium bases.[4] However, low temperature and ...