Synthesis and pharmacological screening of some novel chalconyl derivatives of substituted phenyl semicarbazide

…, SN Pandeya, CS Chauhan, CS Sharma

文献索引：Singh, Hemendra Pratap; Pandeya; Chauhan; Sharma, Chandra Shekhar Medicinal Chemistry Research, 2011 , vol. 20, # 1 p. 74 - 80

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被引用次数: 8

摘要

Abstract In the present study, we have synthesized chalcone and semicarbazide-linked chalonyl derivatives and the titled compounds confirmed by MS, IR, and 1 H NMR techniques. The anticonvulsant activity was determined by maximal electroshock (MES) induced seizure method. A majority of the compounds exhibited significant anticonvulsant activity after intraperitoneal administration. The results show the importance of hydrogen ...