Archiv der Pharmazie

Synthesis and Biological Evaluation of 4??Phenoxy??6, 7??disubstituted Quinolines Possessing Semicarbazone Scaffolds as Selective c??Met Inhibitors

B Qi, H Tao, D Wu, J Bai, Y Shi, P Gong

文献索引：Qi, Baohui; Tao, Haiyan; Wu, Di; Bai, Jinying; Shi, Yandan; Gong, Ping Archiv der Pharmazie, 2013 , vol. 346, # 8 p. 596 - 609

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被引用次数: 9

摘要

ABSTRACT Novel quinoline derivatives bearing acyclic semicarbazones were prepared and their chemical structures as well as the relative stereochemistry were confirmed. All the synthesized compounds were evaluated for their c-Met kinase inhibitory activity and their cytotoxicity against the cell lines HT-29, MKN-45, and MDA-MB-231 in vitro. Several potent compounds were further evaluated against A549 cells. Most compounds displayed ...