Design and synthesis of novel triazole antifungal derivatives by structure-based bioisosterism

…, X Che, W Wang, S Wang, Y Cao, Z Miao, J Yao…

文献索引：Sheng, Chunquan; Che, Xiaoying; Wang, Wenya; Wang, Shengzheng; Cao, Yongbing; Miao, Zhenyuan; Yao, Jianzhong; Zhang, Wannian European Journal of Medicinal Chemistry, 2011 , vol. 46, # 11 p. 5276 - 5282

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被引用次数: 29

摘要

The incidence of life-threatening fungal infections is increasing dramatically. In an attempt to develop novel antifungal agents, our previously synthesized phenoxyalkylpiperazine triazole derivatives were used as lead structures for further optimization. By means of structure-based bioisosterism, triazolone was used as a new bioisostere of oxygen atom. This type of bioisosteric replacement can improve the water solubility without loss of ...