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Synthesis and biological activity of substituted 3-acylmethylene and 3-hydroxy-2-indolones

…, SA Shelenkova, EV Voronina, VO Koz'minykh

文献索引:Koz'minykh; Berezina; Kolla; Shelenkova; Voronina Pharmaceutical Chemistry Journal, 1997 , vol. 31, # 2 p. 83 - 88

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摘要

As is known, 3-acylrnethylene-2-indolones may serve as initial compounds for obtaining various 3-spiro derivatives of hydroxyindole by the Diels-Alder reaction with alkadienes [I, 2]. Analogous compounds with close structures-3-spiroindolones-are formed by the Michael reaction of 3-acylmethylene-2-indolones with various CH-activated carbonyl compounds [3, 4] and enamines [5], and by condensation with binucleophiles such as thiourea, ...