Asymmetric Baeyer-Villiger Oxidations of 4-Mono-and 4, 4-Disubstituted Cyclohexanones by Whole Cells of Engineered Escherichia c oli

MD Mihovilovic, G Chen, S Wang, B Kyte…

文献索引：Mihovilovic; Chen; Wang; Kyte; Rochon; Kayser; Stewart Journal of Organic Chemistry, 2001 , vol. 66, # 3 p. 733 - 738

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被引用次数: 105

摘要

Whole cells of an Escherichia coli strain that overexpresses Acinetobacter sp. NCIB 9871 cyclohexanone monooxygenase have been used for the Baeyer-Villiger oxidations of a variety of 4-mono-and 4, 4-disubstituted cyclohexanones. In cases where comparisons were possible, this new biocatalytic reagent provided lactones with chemical yields and optical purities that were comparable to those obtained from the purified enzyme or a strain of ...