Synthesis of (R)-serine-2-d and its conversion to the broad-spectrum antibiotic fludalanine

PJ Reider, RSE Conn, P Davis, VJ Grenda…

文献索引：Journal of Organic Chemistry, , vol. 52, # 15 p. 3326 - 3334

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被引用次数: 36

摘要

... With the advent of the requirement for large quantities of Fludalanine (1, MK-641) we had to address the practical and economical introduction of deuterium into an organic molecule. ... Scheme IV 0-i-Pr I , IV Y r 8 =(,RAr - 0 J. Org. Chem., Vol. 52, No. 15, 1987 3329 ...