Influence of alkyl-chain fluorination on the action of mammary tumor inhibiting 2, 3-bis (hydroxyphenyl) butanes and 2, 3-bis (hydroxyphenyl) but-2-enes

RW Hartmann, A Heindl, MR Schneider…

文献索引：Hartmann, Rolf W.; Heindl, Alexander; Schneider, Martin R.; Schoenenberger, Helmut Journal of Medicinal Chemistry, 1986 , vol. 29, # 3 p. 322 - 328

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被引用次数: 15

摘要

(TiCl,/Zn/pyridine) of the methoxy-substituted a, a, a-trifluoroacetophenones, separation of the resulting cis-and trans-stilbene derivatives, and ether cleavage with BBr3. The cis- stilbenes were catalytically hydrogenated to give meso-1, 1, 1, 4, 4, 4-hexafluoro-2, 3-bis (4- and 3-hydroxypheny1) butanes 6 and 8. Compounds 2, 4, 6, and 8 showed 2-to 10-fold increased binding affinities for the estradiol receptor (E2R) and enhanced estrogenicity in ...