Acyclic amides as estrogen receptor ligands: synthesis, binding, activity and receptor interaction

…, BS Katzenellenbogen, JA Katzenellenbogen

文献索引：Stauffer, Shaun R.; Sun, Jun; Katzenellenbogen, Benita S.; Katzenellenbogen, John A. Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 6 p. 1293 - 1316

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被引用次数: 60

摘要

We have prepared a series of bisphenolic amides that mimic bibenzyl and homobibenzyl motifs commonly found as substructures in ligands for the estrogen receptor (ER). Representative members were prepared from three classes: N-phenyl benzamides, N- phenyl acetamides, and N-benzyl benzamides; in some cases the corresponding thiocarboxamides and sulfonamides were also prepared. Of these three classes, the N- ...