Synthetic Communications

Novel Asymmetric Synthesis of (S)-Esmolol Using Hydrolytic Kinetic Resolution

AV Narsaiah, JK Kumar

文献索引：Narsaiah, A. Venkat; Kumar, J. Kranthi Synthetic Communications, 2011 , vol. 41, # 11 p. 1603 - 1608

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被引用次数: 8

摘要

Abstract An efficient asymmetric synthesis of (S)-methyl 3-[4-[2-hydroxy-3-(isopropyl amino) propoxy] phenyl] propanoate is described. The key intermediate (S)-methyl 3-[4-(oxiran-2- ylmethoxy) phenyl] propanoate was obtained by hydrolytic kinetic resolution method using Jacobsen catalyst.