Bioorganic & medicinal chemistry letters

Quinic acid derivatives from Pimpinella brachycarpa exert anti-neuroinflammatory activity in lipopolysaccharide-induced microglia

SY Lee, E Moon, SY Kim, KR Lee

文献索引：Lee, Seung Young; Moon, Eunjung; Kim, Sun Yeou; Lee, Kang Ro Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 7 p. 2140 - 2144

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被引用次数: 15

摘要

Five new quinic acid derivatives (1–5), together with 10 known quinic acid derivatives (6– 15), were isolated from the MeOH extract of Pimpinella brachycarpa (Umbelliferae). Their structures were established on the basis of spectroscopic analyses including extensive 2D NMR studies (COSY, HMQC and HMBC). Isolated compounds 1–15 were evaluated for their inhibitory activities on nitric oxide (NO) production in an activated murine microglial cell ...