Carbohydrate research

Towards the synthesis of aryl glucuronides as potential heparanase probes. An interesting outcome in the glycosidation of glucuronic acid with 4-hydroxycinnamic …

AG Pearson, MJ Kiefel, V Ferro, M von Itzstein

文献索引：Pearson, Andrew G.; Kiefel, Milton J.; Ferro, Vito; Von Itzstein, Mark Carbohydrate Research, 2005 , vol. 340, # 13 p. 2077 - 2085

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被引用次数: 24

摘要

This work describes our preliminary efforts towards the development of aryl glucuronides as potential probes for heparanase. During the course of these initial investigations, attempted glycosidation of methyl 2, 3, 4-tri-O-acetyl-α-d-glucopyranosyluronate trichloroacetimidate with 4-hydroxycinnamic acid gave a complex mixture of four different components. These were identified as the 1-cinnamyl glucuronate ester 13, the cinnamyl linked disaccharide ...