Organic letters

A remarkably simple protocol for the N-formylation of amino acid esters and primary amines

M Suchý, AAH Elmehriki, RHE Hudson

文献索引：Suchy, Mojmir; Elmehriki, Adam A. H.; Hudson, Robert H. E. Organic Letters, 2011 , vol. 13, # 15 p. 3952 - 3955

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被引用次数: 46

摘要

During the course of other studies in our laboratory, we wished to prepare a 1-Me-histidine (1-Me-His-OH). The synthesis of 1-Me-His-OH (in 3 steps from 1a) has been described by Jain and Cohen,(4a) and involves the reaction of His-OMe·2HCl (1a) with carbonyldiimidazole (CDI) in DMF as an initial step. A cyclic urea 3 (Scheme 1) is formed during this step, which is subsequently transformed to 1-Me-His-OH.(4a) Initial attempts to repeat the synthesis of 3 ...