Tetrahedron

Studies on amino acids and peptides—IV: 1, 2, 4-triazines from thioacylated amino-acid esters

TP Andersen, ABAG Ghattas, SO Lawesson

文献索引：Andersen,T.P.; Ghattas,A.B.; Lawesson,S.O. Tetrahedron, 1983 , vol. 39, p. 3419

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被引用次数: 28

摘要

Ethyl esters 2 of N-acyl derivatives of glycine, S-alanine, S-phenylalanine, and S-proline, were thionated by use of 2, 4-bis (4-methoxyphenyl)-1, 3, 2, 4-dithiadiphosphetane 2, 4- disulfide (Lawesson's Reagent) 1. The N-thioacyl compounds 3 were reacted with hydrazine hydrate and in most cases a ring-closure reaction took place, giving 1, 2, 4-triazine derivatives 4. The structural proofs of 4 were obtained by 1H, 13C, and 15N NMR ...