Chemical biology & drug design

Antifungal Agents. Part 3: Synthesis and Antifungal Activities of 3??Acylindole Analogs against Phytopathogenic Fungi In Vitro

H Xu, W bin Yang, Q Wang

文献索引：Xu, Hui; Bin Yang, Wen; Wang, Qin Chemical Biology and Drug Design, 2011 , vol. 78, # 5 p. 864 - 868

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被引用次数: 3

摘要

To find more potent antifungal compounds, twenty 3-acylindole analogs were synthesized and bio-evaluated for their antifungal activities against seven phytopathogenic fungi. Structure–activity relationships investigations revealed that 4-or 6-methyl and 3-acetyl or propionyl groups were the important structural properties of 3-acylindoles for the activities. Especially 4-methyl-3-propionylindole, 12, displayed the more potent activities than ...