Abstract A novel approach was adopted for the synthesis of series of new pyrazolyl chalcones (3a–c) by the reaction of 5-chloro-3-methyl-1-phenylpyrazole-4-carboxaldehyde (1) with different 5-acetylbarbituric acid derivatives (2a–c) under thermal solvent-free condition. The chalcones were then converted to the corresponding pyrazolines (4a–c) under the same condition in excellent yields. All the synthesized compounds were ...
[Neumann, Donna M.; Cammarata, Amy; Backes, Gregory; Palmer, Glen E.; Jursic, Branko S. Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 2 p. 813 - 826]
