Synthesis and antifungal activity of substituted 2, 4, 6-pyrimidinetrione carbaldehyde hydrazones

…, A Cammarata, G Backes, GE Palmer, BS Jursic

文献索引：Neumann, Donna M.; Cammarata, Amy; Backes, Gregory; Palmer, Glen E.; Jursic, Branko S. Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 2 p. 813 - 826

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被引用次数: 15

摘要

Abstract Opportunistic fungal infections caused by the Candida spp. are the most common human fungal infections, often resulting in severe systemic infections—a significant cause of morbidity and mortality in at-risk populations. Azole antifungals remain the mainstay of antifungal treatment for candidiasis, however development of clinical resistance to azoles by Candida spp. limits the drugs' efficacy and highlights the need for discovery of novel ...