Tritium-labeled enantiomers of disparlure. Synthesis and in vitro metabolism

GD Prestwich, SM Graham, JW Kuo…

文献索引：Prestwich, Glenn D.; Graham, Steven McG.; Kuo, Jing-Wen; Vogt, Richard G. Journal of the American Chemical Society, 1989 , vol. 111, # 2 p. 636 - 642

全文：HTML全文

被引用次数: 34

摘要

Abstract: Both of the enantiomers of disparlure, the gypsy moth sex attractant, have been prepared at high specific activity (58 Ci/mmol) by homogeneous tritiation of the optically active alkenyl oxiranes. An improved preparation of the racemic disparlure is also described. The radiolabeled epoxides are cleanly converted to a single product by enzymes isolated from adult gypsy moths (Lymantria dispar). Enzymatic activity obtained from male ...