Study of a cyclopamine glucuronide prodrug for the selective chemotherapy of glioblastoma

F Hamon, B Renoux, C Chadéneau, JM Muller…

文献索引：Hamon, Florian; Renoux, Brigitte; Chadeneau, Corinne; Muller, Jean-Marc; Papot, Sebastien European Journal of Medicinal Chemistry, 2010 , vol. 45, # 4 p. 1678 - 1682

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被引用次数: 20

摘要

The first glucuronide prodrug of the hedgehog signaling inhibitor cyclopamine was synthesized. The carbamoyl derivatisation of cyclopamine significantly decreased its toxicity towards the U87 human glioblastoma cell line. However, when the prodrug was incubated ...